Use este identificador para citar ou linkar para este item:
https://locus.ufv.br//handle/123456789/12810
Tipo: | Artigo |
Título: | Synthesis and antiproliferative activity of C-3 functionalized Isobenzofuran-1(3H)-ones |
Autor(es): | Teixeira, Róbson Ricardo Bressan, Gustavo Costa Pereira, Wagner Luiz Ferreira, Joana Gasperazzo Oliveira, Fabrício Marques de Thomaz, Deborah Campos |
Abstract: | A series of thirteen C-3 functionalized isobenzofuran-1(3H)-ones (phtalides) was synthesized via condensation, aromatization, and acetylation reactions. NMR (one and two dimensional experiments), IR, and mass spectrometry analysis allowed confirmation of the identity of the synthesized compounds. The substances were submitted to in vitro bioassays against U937 (lymphoma) and K562 (myeloid leukemia) cancer cell lines using the MTT cytotoxicity assay. Some derivatives inhibited 90% of cell viability at 100 µM. Also, two phtalides presented biological activity superior than that of etoposide (VP16), a commercial drug used as a positive control in the assays. In silico drug properties of the evaluated compounds were calculated and the results are discussed. |
Palavras-chave: | Phtalides Antiproliferative activity Isobenzofuran-1(3H)-one |
Editor: | Molecules |
Tipo de Acesso: | Open Access |
URI: | https://doi.org/10.3390/molecules18021881 http://www.locus.ufv.br/handle/123456789/12810 |
Data do documento: | 1-Fev-2013 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
molecules-18-01881.pdf | Texto completo | 269,48 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.