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https://locus.ufv.br//handle/123456789/13716
Tipo: | Artigo |
Título: | N-rich protein (NRP)-mediated cell death signaling |
Autor(es): | Reis, Pedro A.B. Fontes, Elizabeth P.B. |
Abstract: | Upon disruption of ER homeostasis, plant cells activate at least two branches of the unfolded protein response (UPR) through IRE1-like and ATAF6-like transducers, resulting in the upregulation of ER-resident molecular chaperones and the activation of the ER-associated degradation protein system. Here, we discuss a new ER stress response pathway in plants that is associated with an osmotic stress response in transducing a cell death signal. Both ER and osmotic stress induce the expression of the novel transcription factor GmERD15, which binds and activates N-rich protein (NRP) promoters to induce NRP expression and cause the upregulation of GmNAC6, an effector of the cell death response. In contrast to this activation mechanism, the ER-resident molecular chaperone binding protein (BiP) attenuates the propagation of the cell death signal by modulating the expression and activity of components of the ER and osmotic stress-induced NRP-mediated cell death signaling. This interaction attenuates dehydration-induced cell death and promotes a better adaptation of BiP-overexpressing transgenic lines to drought. |
Palavras-chave: | Endoplasmic reticulum stress Osmotic stress Cell death response N-rich proteins GmNAC6 ERD15 NRP-A NRP-B |
Editor: | Plant Signaling & Behavior |
Tipo de Acesso: | Open Access |
URI: | https://doi.org/10.4161/psb.20111 http://www.locus.ufv.br/handle/123456789/13716 |
Data do documento: | 22-Mar-2012 |
Aparece nas coleções: | Artigos |
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Arquivo | Descrição | Tamanho | Formato | |
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N rich protein NRP mediated cell death signaling.pdf | Texto completo | 345,62 kB | Adobe PDF | Visualizar/Abrir |
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