Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/13716
Tipo: Artigo
Título: N-rich protein (NRP)-mediated cell death signaling
Autor(es): Reis, Pedro A.B.
Fontes, Elizabeth P.B.
Abstract: Upon disruption of ER homeostasis, plant cells activate at least two branches of the unfolded protein response (UPR) through IRE1-like and ATAF6-like transducers, resulting in the upregulation of ER-resident molecular chaperones and the activation of the ER-associated degradation protein system. Here, we discuss a new ER stress response pathway in plants that is associated with an osmotic stress response in transducing a cell death signal. Both ER and osmotic stress induce the expression of the novel transcription factor GmERD15, which binds and activates N-rich protein (NRP) promoters to induce NRP expression and cause the upregulation of GmNAC6, an effector of the cell death response. In contrast to this activation mechanism, the ER-resident molecular chaperone binding protein (BiP) attenuates the propagation of the cell death signal by modulating the expression and activity of components of the ER and osmotic stress-induced NRP-mediated cell death signaling. This interaction attenuates dehydration-induced cell death and promotes a better adaptation of BiP-overexpressing transgenic lines to drought.
Palavras-chave: Endoplasmic reticulum stress
Osmotic stress
Cell death response
N-rich proteins
GmNAC6
ERD15
NRP-A
NRP-B
Editor: Plant Signaling & Behavior
Tipo de Acesso: Open Access
URI: https://doi.org/10.4161/psb.20111
http://www.locus.ufv.br/handle/123456789/13716
Data do documento: 22-Mar-2012
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