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Antioxidant, antiproliferative, and immunostimulatory effects of cell wall α-d-mannan fractions from Kluyveromyces marxianus

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dc.contributor.author Galinari, Éder
dc.contributor.author Almeida-Lima, Jailma
dc.contributor.author Macedo, Gorete Ribeiro
dc.contributor.author Mantovani, Hilário Cuquetto
dc.contributor.author Rocha, Hugo Alexandre Oliveira
dc.date.accessioned 2018-04-04T10:14:10Z
dc.date.available 2018-04-04T10:14:10Z
dc.date.issued 2017-11-11
dc.identifier.issn 01418130
dc.identifier.uri https://doi.org/10.1016/j.ijbiomac.2017.11.053
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/18614
dc.description.abstract This study evaluated the antioxidant, antiproliferative, and immunostimulatory properties of cell wall α-d-mannan fractions from yeast Kluyveromyces marxianus CCT7735. Filter centrifugation was used to obtain four fractions (KMM-1, KMM-2, KMM-3, and KMM-4) with molecular weight ranging from 7.6 to 75.1 kDa. KMM-1 and KMM-2 comprised D-mannose with traces of D-glucose, whereas other fractions contained only D-mannose. Total sugar found in samples ranged from 85.9% to 96.1%, while protein and phenolic contents were 1.21% and 0.41%, respectively. Although only KMM-1 was able to scavenge superoxide radicals, all fractions presented total antioxidant capacity as well as reducing power, hydroxyl-radical scavenging, and copper- and iron-chelating activities. No fraction was cytotoxic to HeLa cells. However, all samples inhibited the proliferation of the tumor cell Hep-G2 and presented minor cytotoxicity against normal 3T3 cells. All fractions showed mitogenic activity in macrophages and all, except KMM-4, induced nitric oxide production in macrophages, suggestive of their immunostimulatory effects. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher International Journal of Biological Macromolecules pt-BR
dc.relation.ispartofseries v. 109, p. 837-846, April 2018 pt-BR
dc.rights Elsevier B.V. All rights reserved. pt-BR
dc.subject Copper-chelating pt-BR
dc.subject Iron-chelating pt-BR
dc.subject Mitogenic activity pt-BR
dc.subject Cell wall polysaccharide pt-BR
dc.subject Nitric oxide pt-BR
dc.title Antioxidant, antiproliferative, and immunostimulatory effects of cell wall α-d-mannan fractions from Kluyveromyces marxianus en
dc.type Artigo pt-BR


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  • Artigos [256]
    Artigos Técnico-científicos na área de Microbiologia

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