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https://locus.ufv.br//handle/123456789/18965
Tipo: | Artigo |
Título: | CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis |
Autor(es): | Batista, Rodrigo Siqueira Gomes, Andréia Patrícia Azevedo, Sarah Fumian Milward Vitorino, Rodrigo Roger Mendonça, Eduardo Gomes de Sousa, Flávio Oliveira de Oliveira, Alcione de Paiva Cerqueira, Fábio Ribeiro Paula, Sérgio Oliveira de Oliveira, Maria Goreti de Almeida |
Abstract: | The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis. |
Palavras-chave: | Regulatory T lymphocytes Sepsis/pathophysiology Sepsis/therapy Inflammation Immunity Computer simulation |
Editor: | Revista Brasileira de Terapia Intensiva |
Tipo de Acesso: | Open Access |
URI: | http://dx.doi.org/10.1590/S0103-507X2012000300014 http://www.locus.ufv.br/handle/123456789/18965 |
Data do documento: | 28-Set-2012 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf | Texto completo | 123,9 kB | Adobe PDF | Visualizar/Abrir |
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