Use este identificador para citar ou linkar para este item:
https://locus.ufv.br//handle/123456789/19427
Tipo: | Artigo |
Título: | Hederagenin as a triterpene template for the development of new antitumor compounds |
Autor(es): | Rodríguez-Hernández, Diego Demuner, Antonio J. Barbosa, Luiz C.A. Csuk, René Heller, Lucie |
Abstract: | In this study, a series of novel C-28 esters and amides derivatives of hederagenin (He) were designed and synthesized in attempt to develop potent antitumor agents. Their structures were confirmed by MS, IR, 1H NMR and ^13C NMR spectroscopic analyses and their cytotoxic activities were screened in SRB assays using a panel of six human cancer cell lines. Although most of the compounds displayed moderate to high levels of cytotoxic activity they were all more potent than the natural product He. The most active compounds had either an ethylpyrimidinyl (27) or an ethylpyrrolidinyl (28) substituent, with EC50 in the range of 1.1–6.5 μM for six human cancer cell lines. Notably, this corresponds to an approximately 30-fold times greater potency than He. |
Palavras-chave: | Sapindus saponaria Pentacyclic triterpenes Hederagenin derivatives SRB assay Folk medicinal plant |
Editor: | European Journal of Medicinal Chemistry |
Tipo de Acesso: | Elsevier Masson SAS. |
URI: | https://doi.org/10.1016/j.ejmech.2015.10.006 http://www.locus.ufv.br/handle/123456789/19427 |
Data do documento: | 13-Nov-2015 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo.pdf Until 2100-12-31 | texto completo | 831,75 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.