Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/19432
Tipo: Artigo
Título: Higher plasma lipopolysaccharide concentrations are associated with less favorable phenotype in overweight/obese men
Autor(es): Moreira, Ana Paula Boroni
Alves, Raquel Duarte Moreira
Teixeira, Tatiana Fiche Salles
Macedo, Viviane Silva
Oliveira, Leandro Licursi de
Costa, Neuza Maria Brunoro
Bressan, Josefina
Peluzio, Maria do Carmo Gouveia
Mattes, Richard
Alfenas, Rita de Cássia Gonçalves
Abstract: Lipopolysaccharide (LPS) from the outer membrane of gram-negative bacteria might be an inflammation trigger in adipose tissue. It has recently been proposed that there is a link between adipose tissue distribution and blood LPS. However, the number of studies on this topic is scarce, and further investigation in humans is required. In this study, we explored the association between plasma LPS concentrations and body fat distribution, as well as the biochemical parameters that may indicate the presence of metabolic disorders. Sixty-seven young adult men with body mass index of 26–35 kg/m2 were evaluated. Anthropometry, body composition and body fat distribution, blood pressure, energy expenditure, physical activity level, dietary intake, and biochemical parameters were assessed. Men with median plasma LPS ≥ 0.9 EU/mL presented higher sagittal abdominal diameter, trunk fat percentage, and android fat percentage, and mass, insulin and alanine aminotransferase concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), and beta cell dysfunction (HOMA-B) than those with lower plasma LPS. LPS correlated positively with the trunk fat percentage, and android fat percentage, and mass, insulin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase concentrations, as well as HOMA-IR and HOMA-B. Our results suggest that a higher plasma LPS concentration is associated with a less favorable phenotype as characterized by higher central adiposity, higher values of HOMA-IR, and beta cell function impairment in overweight/obese men.
Palavras-chave: Lipopolysaccharide
Abdominal obesity
Insulin
Homeostasis model assessment
Editor: European Journal of Nutrition
Tipo de Acesso: Springer-Verlag Berlin Heidelberg
URI: https://doi.org/10.1007/s00394-014-0817-6
http://www.locus.ufv.br/handle/123456789/19432
Data do documento: 18-Dez-2014
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