Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/12557
Tipo: Artigo
Título: The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi
Autor(es): Pereira, Wagner Luiz
Vasconcellos, Raphael de Souza
Mariotini-Moura, Christiane
Gomes, Rodrigo Saar
Firmino, Rafaela de Cássia
Silva, Adalberto Manoel da
Silva Júnior, Abelardo
Bressan, Gustavo Costa
Almeida, Márcia Rogéria
Afonso, Luís Carlos Crocco
Teixeira, Róbson Ricardo
Fietto, Juliana Lopes Rangel
Abstract: Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expensive for routine use in developing countries. These facts call for safer, cheaper, and more effective new antileishmanial drugs. In this investigation, we describe the results of the assessment of the activities of a series of isobenzofuran-1(3H)-ones (phtalides) against Leishmania (Leishmania) infantum chagasi, which is the main causative agent of visceral leishmaniasis in the New World. The compounds were tested at concentrations of 100, 75, 50, 25 and 6.25 µM over 24, 48, and 72 h. After 48 h of treatment at the 100 µM concentration, compounds 7 and 8 decreased parasite viability to 4% and 6%, respectively. The concentration that gives half-maximal responses (LC50) for the antileishmanial activities of compounds 7 and 8 against promastigotes after 24 h were 60.48 and 65.93 µM, respectively. Additionally, compounds 7 and 8 significantly reduced parasite infection in macrophages.
Palavras-chave: Leishmania (L.) infantum chagasi
Visceral leishmaniasis
Isobenzofuranones
Phthalides
In vitro leishmanicidal activity
Editor: Molecules
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.3390/molecules201219857
http://www.locus.ufv.br/handle/123456789/12557
Data do documento: 14-Dez-2015
Aparece nas coleções:Artigos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
molecules-20-19857.pdftexto completo2,32 MBAdobe PDFThumbnail
Visualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.