Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/12810
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dc.contributor.authorTeixeira, Róbson Ricardo
dc.contributor.authorBressan, Gustavo Costa
dc.contributor.authorPereira, Wagner Luiz
dc.contributor.authorFerreira, Joana Gasperazzo
dc.contributor.authorOliveira, Fabrício Marques de
dc.contributor.authorThomaz, Deborah Campos
dc.date.accessioned2017-11-07T11:09:50Z
dc.date.available2017-11-07T11:09:50Z
dc.date.issued2013-02-01
dc.identifier.issn14203049
dc.identifier.urihttps://doi.org/10.3390/molecules18021881
dc.identifier.urihttp://www.locus.ufv.br/handle/123456789/12810
dc.description.abstractA series of thirteen C-3 functionalized isobenzofuran-1(3H)-ones (phtalides) was synthesized via condensation, aromatization, and acetylation reactions. NMR (one and two dimensional experiments), IR, and mass spectrometry analysis allowed confirmation of the identity of the synthesized compounds. The substances were submitted to in vitro bioassays against U937 (lymphoma) and K562 (myeloid leukemia) cancer cell lines using the MTT cytotoxicity assay. Some derivatives inhibited 90% of cell viability at 100 µM. Also, two phtalides presented biological activity superior than that of etoposide (VP16), a commercial drug used as a positive control in the assays. In silico drug properties of the evaluated compounds were calculated and the results are discussed.en
dc.formatpdfpt-BR
dc.language.isoengpt-BR
dc.publisherMoleculespt-BR
dc.relation.ispartofseries18(2), p. 1881-1896, February 2013pt-BR
dc.rightsOpen Accesspt-BR
dc.subjectPhtalidespt-BR
dc.subjectAntiproliferative activitypt-BR
dc.subjectIsobenzofuran-1(3H)-onept-BR
dc.titleSynthesis and antiproliferative activity of C-3 functionalized Isobenzofuran-1(3H)-onesen
dc.typeArtigopt-BR
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