Zero-inflated Poisson regression models for QTL mapping applied to tick-resistance in a Gyr x Holstein F2 population

Show simple item record Silva, Fabyano Fonseca Tunin, Karen P. Rosa, Guilherme J.M. Silva, Marcos V.B. da Azevedo, Ana Luisa Souza Verneque, Rui da Silva Machado, Marco Antonio Packer, Irineu Umberto 2017-11-08T12:50:06Z 2017-11-08T12:50:06Z 2011-10-28
dc.identifier.issn 1415-4757
dc.description.abstract Nowadays, an important and interesting alternative in the control of tick-infestation in cattle is to select resistant animals, and identify the respective quantitative trait loci (QTLs) and DNA markers, for posterior use in breeding programs. The number of ticks/animal is characterized as a discrete-counting trait, which could potentially follow Poisson distribution. However, in the case of an excess of zeros, due to the occurrence of several noninfected animals, zero-inflated Poisson and generalized zero-inflated distribution (GZIP) may provide a better description of the data. Thus, the objective here was to compare through simulation, Poisson and ZIP models (simple and generalized) with classical approaches, for QTL mapping with counting phenotypes under different scenarios, and to apply these approaches to a QTL study of tick resistance in an F2 cattle (Gyr x Holstein) population. It was concluded that, when working with zero-inflated data, it is recommendable to use the generalized and simple ZIP model for analysis. On the other hand, when working with data with zeros, but not zero-inflated, the Poisson model or a data-transformation-approach, such as square-root or Box-Cox transformation, are applicable. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Genetics and Molecular Biology pt-BR
dc.relation.ispartofseries vol. 34, n. 4, p. 575-581, Oct. 2011 pt-BR
dc.rights Open Access pt-BR
dc.subject Dairy cattle pt-BR
dc.subject Tick infestation pt-BR
dc.subject QTL regression pt-BR
dc.subject Generalized linear model pt-BR
dc.title Zero-inflated Poisson regression models for QTL mapping applied to tick-resistance in a Gyr x Holstein F2 population en
dc.type Artigo pt-BR

Files in this item

This item appears in the following Collection(s)

  • Artigos [94]
    Artigos Técnico-científicos na área de Estatística

Show simple item record

Search DSpace


My Account