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Regeneration of peripheral nerve fibres following Haloxon-induced degeneration

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dc.contributor.author Souza, Maria Veronica de
dc.contributor.author Graça, Dominguita Luhers
dc.contributor.author Ferrão, Sandro Narciso Nunes
dc.contributor.author Contesini, Emerson Antônio
dc.date.accessioned 2018-01-29T13:30:31Z
dc.date.available 2018-01-29T13:30:31Z
dc.date.issued 1995-11-15
dc.identifier.issn 1678-4456
dc.identifier.uri http://dx.doi.org/10.11606/issn.2318-3659.v33i4p231-234
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/16885
dc.description.abstract Delayed neurotoxicity has been associated with organophosphorus poisoning for years. In order to study such condition in sheep, 11 animals were given either one or two high doses of Haloxon. Exposed sheep were observed daily and between 16 and 25 days after adm inistration neurological signs as incoordination and ataxia were detected in six of them. Biopsies of tibial and laryngeal nerves were performed as soon as neurotoxicity was diagnosed, and after death fragm ents of selected nerves were collected together with CNS tissues for light and electron microscopy and teased fiber studies. Laryngeal, tibial and sciatic nerves showed the most pronouced changes, consisting chiefly of wallerian degeneration that was seen either as a single fiber or as a com plete fascicle feature. Exams performed after death clearly showed regenerating fascicles with axonal sprouts growing within a Schwann cell old basal lamina, and some thinly myelinated axonal sprouts. en
dc.description.abstract Eventos de neurotoxicidade tardia têm sido freqüentemente associados com intoxicação crônica por organofosforados. Com a finalidade de estudar essa condição em ovelhas, 11 animais receberam uma ou duas doses de 353 ou 500 mg/kg de Haloxon via oral. Os animais intoxicados foram observados diariamente e, entre 16 e 25 dias após a intoxicação, sinais neurológicos de incoordenação e ataxia foram detectados em seis deles. Foram realizadas biópsias de nervos tibiais e laríngeos tão logo a neurotoxicidade foi diagnosticada e, após a morte, fragmentos de nervos periféricos selecionados foram colhidos, juntamente com o sistema nervoso central, para estudos de microscopia óptica, eletrônica de transmissão e de fibras desfiadas. Os nervos tibiais, laríngeos e ciáticos mostraram as alterações mais pronunciadas, que consistiram em degeneração walleriana, ora de uma única fibra, ora de todo um fascículo. Após a morte, exames histológicos revelaram fibras em regeneração com brotamentos axonais crescendo dentro de membranas de células de Schwann, alguns exibindo bainhas finas de mielina. pt-BR
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Brazilian Journal of Veterinary Research and Animal Science pt-BR
dc.relation.ispartofseries v.33, n.4, p.231-234, 1996 pt-BR
dc.rights Open Access pt-BR
dc.subject Haloxon pt-BR
dc.subject Poisoning pt-BR
dc.subject Sheep pt-BR
dc.subject Neurotoxins pt-BR
dc.subject Nerve regeneration pt-BR
dc.title Regeneration of peripheral nerve fibres following Haloxon-induced degeneration en
dc.type Artigo pt-BR


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  • Artigos [566]
    Artigos Técnico-científicos na área de Veterinária

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