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In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

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dc.contributor.author Sartorelli, Patricia
dc.contributor.author Santana, Jefferson S.
dc.contributor.author Guadagnin, Rafael C.
dc.contributor.author Lago, João Henrique G.
dc.contributor.author Pinto, Érika G.
dc.contributor.author Tempone, André G.
dc.contributor.author Stefani, Hélio A.
dc.contributor.author Soares, Marisi G.
dc.contributor.author Silva, Adalberto M. da
dc.date.accessioned 2018-02-06T12:55:58Z
dc.date.available 2018-02-06T12:55:58Z
dc.date.issued 2012-11-23
dc.identifier.issn 01004042
dc.identifier.uri http://dx.doi.org/10.1590/S0100-40422012000400017
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/17330
dc.description.abstract Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Química Nova pt-BR
dc.relation.ispartofseries Vol. 35, N. 4, p.743-747, 2012 pt-BR
dc.rights Open Access pt-BR
dc.subject Schinus terebinthifolius Raddi pt-BR
dc.subject Anacardiaceae pt-BR
dc.subject Trypanocidal activity pt-BR
dc.title In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae) en
dc.type Artigo pt-BR


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    Artigos Técnico-científicos na área de Química

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