Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/18783
Tipo: Artigo
Título: Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects
Autor(es): Epifânio, Andreza de Paula Santos
Balbino, Karla Pereira
Jorge, Monica De Paula
Ribeiro, Sonia M.R.
Moreira, Ana Vládia Bandeira
Oliveira, Jerusa Maria
Oliveira, Leandro Licursi
Hermsdorff, Helen Hermana Miranda
Abstract: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.
Palavras-chave: Reactive
Nitrogen species
Inflammation
Superoxide
Dismutase
Food intake
End-stage renal disease
Editor: Nutricion Hospitalaria
Tipo de Acesso: Arán Ediciones S.L.
URI: http://dx.doi.org/10.20960/nh.1319
http://www.locus.ufv.br/handle/123456789/18783
Data do documento: 28-Abr-2017
Aparece nas coleções:Artigos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
artigo.pdf
  Until 2100-12-31
Texto completo797,1 kBAdobe PDFVisualizar/Abrir ACESSO RESTRITO


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.