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https://locus.ufv.br//handle/123456789/18783
Tipo: | Artigo |
Título: | Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
Autor(es): | Epifânio, Andreza de Paula Santos Balbino, Karla Pereira Jorge, Monica De Paula Ribeiro, Sonia M.R. Moreira, Ana Vládia Bandeira Oliveira, Jerusa Maria Oliveira, Leandro Licursi Hermsdorff, Helen Hermana Miranda |
Abstract: | Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population. |
Palavras-chave: | Reactive Nitrogen species Inflammation Superoxide Dismutase Food intake End-stage renal disease |
Editor: | Nutricion Hospitalaria |
Tipo de Acesso: | Arán Ediciones S.L. |
URI: | http://dx.doi.org/10.20960/nh.1319 http://www.locus.ufv.br/handle/123456789/18783 |
Data do documento: | 28-Abr-2017 |
Aparece nas coleções: | Artigos |
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Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | Texto completo | 797,1 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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