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Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Maximiller D. L. | |
dc.contributor.author | Reis, Pedro A. B. | |
dc.contributor.author | Valente, Maria Anete S. | |
dc.contributor.author | Irsigler, André S. T. | |
dc.contributor.author | Carvalho, Claudine M. | |
dc.contributor.author | Loureiro, Marcelo E. | |
dc.contributor.author | Aragão, Francisco J. L. | |
dc.contributor.author | Boston, Rebecca S. | |
dc.contributor.author | Fietto, Luciano G. | |
dc.contributor.author | Fontes, Elizabeth P. B. | |
dc.date.accessioned | 2018-04-23T17:37:03Z | |
dc.date.available | 2018-04-23T17:37:03Z | |
dc.date.issued | 2008-05-19 | |
dc.identifier.issn | 1083351X | |
dc.identifier.uri | https://doi.org/10.1074/jbc.M802654200 | |
dc.identifier.uri | http://www.locus.ufv.br/handle/123456789/19047 | |
dc.description.abstract | NRPs (N-rich proteins) were identified as targets of a novel adaptive pathway that integrates endoplasmic reticulum (ER) and osmotic stress signals based on coordinate regulation and synergistic up-regulation by tunicamycin and polyethylene gly- col treatments. This integrated pathway diverges from the molecular chaperone-inducing branch of the unfolded protein response (UPR) in several ways. While UPR-specific targets were inversely regulated by ER and osmotic stresses, NRPs required both signals for full activation. Furthermore, BiP (binding protein) overexpression in soybean prevented activa- tion of the UPR by ER stress inducers, but did not affect activa- tion of NRPs. We also found that this integrated pathway trans- duces a PCD signal generated by ER and osmotic stresses that result in the appearance of markers associated with leaf senes- cence. Overexpression of NRPs in soybean protoplasts induced caspase-3-like activity and promoted extensive DNA fragmen- tation. Furthermore, transient expression of NRPs in planta caused leaf yellowing, chlorophyll loss, malondialdehyde pro- duction, ethylene evolution, and induction of the senescence marker gene CP1. This phenotype was alleviated by the cytoki- nin zeatin, a potent senescence inhibitor. Collectively, these results indicate that ER stress induces leaf senescence through activation of plant-specific NRPs via a novel branch of the ER stress response. | en |
dc.format | pt-BR | |
dc.language.iso | eng | pt-BR |
dc.publisher | The Journal of biological chemistry | pt-BR |
dc.relation.ispartofseries | v. 283, n. 29, p. 20209 –20219, July 2008 | pt-BR |
dc.rights | American Society for Biochemistry and Molecular Biology, Inc. | pt-BR |
dc.subject | Endoplasmic reticulum | pt-BR |
dc.subject | Asparagine-rich | pt-BR |
dc.title | A New branch of endoplasmic reticulum stress signaling and the osmotic signal converge on Plant-specific Asparagine-rich proteins to promote cell death | en |
dc.type | Artigo | pt-BR |
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