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dc.contributor.authorSarandy, Mariáurea Matias
dc.contributor.authorMiranda, Lyvia Lopes
dc.contributor.authorAltoé, Luciana Schulthais
dc.contributor.authorNovaes, Rômulo Dias
dc.contributor.authorZanuncio, Virgínia Vinha
dc.contributor.authorLeite, João Paulo Viana
dc.contributor.authorGonçalves, Reggiani Vilela
dc.date.accessioned2018-06-21T10:39:02Z
dc.date.available2018-06-21T10:39:02Z
dc.date.issued2018-04-12
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0195786
dc.identifier.urihttp://www.locus.ufv.br/handle/123456789/20199
dc.description.abstractNatural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no. 730/2014). After anesthesia, three circular wounds (12mm diameter) were made in the animals, which were randomly separated into five treatments: Sal, saline; VO, ointment vehicles (lanolin and Vaseline); SS, positive control (silver sulfadiazine 1%); LE 5, freeze-dried extract 5%; and LE 10, lyophilized extract 10%. The animals were treated with the ointment daily for 21 days. Every seven days, the area and the rate of wound contraction were evaluated. Tissue samples were removed for histopathological analysis of the number of mast cells, elastic and collagen fibers, and biochemical analyses, quantification of malondialdehyde (MDA), carbonylated proteins (PCN), superoxide dismutase (SOD), catalase (CAT), transforming growth factor β (TGF-β), Interleukin 10 (IL-10) and tumor necrosis factor (TNF). The number of mast cells, collagen and elastic fibers in the rat wounds were higher in the treatments with the plant. The extract also stimulated the activity of antioxidant enzymes, particularly SOD, presenting high levels, and maintained low levels of PCN. The TGF-β and IL-10 concentration was higher in the LE5 and LE10 treatment of the extract than in the Sal, OV and SS treatments on day 7. The ointment based on S. pseudoquina closed the wound faster and accelerated wound healing in animals.en
dc.formatpdfpt-BR
dc.language.isoengpt-BR
dc.publisherPlos Onept-BR
dc.relation.ispartofseriesVolume 13, Issue 4, e0195786, April 2018pt-BR
dc.rightsOpen Accesspt-BR
dc.subjectMorphological reorganizationpt-BR
dc.subjectScar tissuept-BRpt-BR
dc.subjectRatspt-BR
dc.titleStrychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in ratsen
dc.typeArtigopt-BR
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