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p-Sulfonic acid calixarenes as efficient and reusable organocatalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones

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dc.contributor.author Silva, Daniel L. da
dc.contributor.author Fernandes, Sergio A.
dc.contributor.author Sabino, Adão A.
dc.contributor.author Fátima, Ângelo de
dc.date.accessioned 2018-08-23T12:21:50Z
dc.date.available 2018-08-23T12:21:50Z
dc.date.issued 2011-11-30
dc.identifier.issn 0040-4039
dc.identifier.uri https://doi.org/10.1016/j.tetlet.2011.08.175
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/21370
dc.description.abstract A new and efficient methodology is proposed for obtaining 3,4-dihydropyrimidin-2(1H)-ones/-thiones through Biginelli reactions. It is based on the use of less than the stoichiometric amount of p-sulfonic acid calixarenes as organocatalysts. A number of aromatic aldehydes as well as urea or thiourea can be employed for successfully synthesizing the corresponding Biginelli adducts. The described methodology is devoid of metal-containing catalysts, which in turn is very attractive for safely producing 3,4-dihydropyrimidin-2-(1H)-ones/-thiones of pharmacological interest. In addition, the catalyst efficiency is not compromised after its successive use in reactions. This is the first report about the application of calixarenes as catalysts in the multicomponent Biginelli reaction. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Tetrahedron Letters pt-BR
dc.relation.ispartofseries volume 52, páginas 6328–6330, novembro 2011 pt-BR
dc.rights Open Access pt-BR
dc.subject Calixarene pt-BR
dc.subject p-Sulfonic acid calix[4]arene pt-BR
dc.subject Organocatalysis pt-BR
dc.subject Biginelli reaction pt-BR
dc.subject 3,4-Dihydropyrimidin-2(1H)-one pt-BR
dc.subject 3,4-Dihydropyrimidin-2(1H)-thione pt-BR
dc.title p-Sulfonic acid calixarenes as efficient and reusable organocatalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones en
dc.type Artigo pt-BR


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    Artigos Técnico-científicos na área de Química

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