Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda

Show simple item record Santos, Marcelo H. dos Rocha, Cláudia Q. da Vilela, Fabiana C. Cecília, Flávia V. Santa Cavalcante, Gustavo P. Vilegas, Wagner Paiva, Alexandre Giusti 2018-09-06T10:02:24Z 2018-09-06T10:02:24Z 2015-05
dc.identifier.issn 1981-528X
dc.description.abstract Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Revista Brasileira de Farmacognosia pt-BR
dc.relation.ispartofseries v. 25, n. 03, p. 228- 232, May- June 2015 pt-BR
dc.rights Elsevier B.V. pt-BR
dc.subject Arrabidaea brachypoda pt-BR
dc.subject Inflammation pt-BR
dc.subject Natural product pt-BR
dc.subject Pain pt-BR
dc.subject Triterpene pt-BR
dc.title Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda en
dc.type Artigo pt-BR

Files in this item

This item appears in the following Collection(s)

  • Artigos [378]
    Artigos Técnico-científicos na área de Química

Show simple item record

Search DSpace


My Account