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Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda

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dc.contributor.author Santos, Marcelo H. dos
dc.contributor.author Rocha, Cláudia Q. da
dc.contributor.author Vilela, Fabiana C.
dc.contributor.author Cecília, Flávia V. Santa
dc.contributor.author Cavalcante, Gustavo P.
dc.contributor.author Vilegas, Wagner
dc.contributor.author Paiva, Alexandre Giusti
dc.date.accessioned 2018-09-06T10:02:24Z
dc.date.available 2018-09-06T10:02:24Z
dc.date.issued 2015-05
dc.identifier.issn 1981-528X
dc.identifier.uri http://dx.doi.org/10.1016/j.bjp.2015.03.005
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/21645
dc.description.abstract Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Revista Brasileira de Farmacognosia pt-BR
dc.relation.ispartofseries v. 25, n. 03, p. 228- 232, May- June 2015 pt-BR
dc.rights Elsevier B.V. pt-BR
dc.subject Arrabidaea brachypoda pt-BR
dc.subject Inflammation pt-BR
dc.subject Natural product pt-BR
dc.subject Pain pt-BR
dc.subject Triterpene pt-BR
dc.title Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda en
dc.type Artigo pt-BR


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  • Artigos [378]
    Artigos Técnico-científicos na área de Química

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