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Virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs for inhibition of quorum sensing and biofilm formation in Salmonella

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dc.contributor.author Almeida, Felipe Alves de
dc.contributor.author Vargas, Erika Lorena Giraldo
dc.contributor.author Carneiro, Deisy Guimarães
dc.contributor.author Pinto, Uelinton Manoel
dc.contributor.author Vanetti, Maria Cristina Dantas
dc.date.accessioned 2018-09-11T11:28:24Z
dc.date.available 2018-09-11T11:28:24Z
dc.date.issued 2018-08
dc.identifier.issn 08824010
dc.identifier.uri https://doi.org/10.1016/j.micpath.2018.05.014
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/21738
dc.description.abstract Salmonella belongs to the Enterobacteriaceae family which is widely distributed in the environment due to its adaptive capacity to stress conditions. In addition, Salmonella is able to perform a type of cell-to-cell communication called quorum sensing, which leads to differential gene expression. The quorum sensing system mediated by AI-1, acyl homoserine lactones (AHLs), is incomplete in Salmonella because the luxI homolog gene, which encodes for AI-1 synthase, is missing in the genome. However, a homologue of LuxR, known as SdiA, is present and allows the detection of signaling molecules produced by other species of bacteria, leading to regulation of gene expression, mainly related to virulence and biofilm formation. Thus, in view of the importance of quorum sensing on the physiology regulation of microorganisms, the aim of the present study was to perform a virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs (NASIDs) for inhibition of quorum sensing by molecular docking and biofilm formation in Salmonella. In general, most plant compounds and all NSAIDs bound in, at least, one of the three modeled structures of SdiA proteins of Salmonella Enteritidis PT4 578. In addition, many tested compounds had higher binding affinities than the AHLs and the furanones which are inducers and inhibitors of quorum sensing, respectively. The Z-phytol and lonazolac molecules were good candidates for the in vitro inhibition tests of quorum sensing mediated by AI-1 and biofilm formation in Salmonella. Thus, this study directs future prospecting of plant extracts for inhibition of quorum sensing mechanism depending on AHL and biofilm formation. In addition, the use of inhibitors of quorum sensing and biofilm formation can be combined with antibiotics for better treatment efficacy, as well as the use of these compounds to design new drugs. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Microbial Pathogenesis pt-BR
dc.relation.ispartofseries v. 121, p. 369- 388, august 2018 pt-BR
dc.rights Elsevier Ltd. pt-BR
dc.subject Anti-biofilm pt-BR
dc.subject Lonazolac pt-BR
dc.subject Quorum quenching pt-BR
dc.subject SdiA protein pt-BR
dc.subject Z-phytol pt-BR
dc.title Virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs for inhibition of quorum sensing and biofilm formation in Salmonella en
dc.type Artigo pt-BR


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  • Artigos [268]
    Artigos Técnico-científicos na área de Microbiologia

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