Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/21782
Tipo: Artigo
Título: Effects of vascularization on cancer nanochemotherapy outcomes
Autor(es): Paiva, L. R.
Ferreira, S. C.
Martins, M. L.
Abstract: Cancer therapy requires anticancer agents capable of efficient and uniform systemic delivery. One promising route to their development is nanotechnology. Here, a previous model for cancer chemotherapy based on a nanosized drug carrier (Paiva et al., 2011) is extended by including tissue vasculature and a three-dimensional growth. We study through computer simulations the therapy against tumors demanding either large or small nutrient supplies growing under different levels of tissue vascularization. Our results indicate that highly vascularized tumors demand more aggressive therapies (larger injected doses administrated at short intervals) than poorly vascularized ones. Furthermore, nanoparticle endocytic rate by tumor cells, not its selectivity, is the major factor that determines the therapeutic success. Finally, our finds indicate that therapies combining cytotoxic agents with antiangiogenic drugs that reduce the abnormal tumor vasculature, instead of angiogenic drugs that normalize it, can lead to successful treatments using feasible endocytic rates and administration intervals.
Palavras-chave: Cancer
Nanochemotherapy
Tumoral vasculature
Multiscale modeling
Editor: Physica A: Statistical Mechanics and its Applications
Tipo de Acesso: Open Access
URI: https://doi.org/10.1016/j.physa.2016.02.065
http://www.locus.ufv.br/handle/123456789/21782
Data do documento: 1-Ago-2016
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