Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/21960
Tipo: Artigo
Título: Fertility in male rats: Disentangling adverse effects of arsenic compounds
Autor(es): Lima, Graziela Domingues de Almeida
Sertorio, Marcela Nascimento
Souza, Ana Cláudia Ferreira
Menezes, Tatiana Prata
Mouro, Viviane Gorete Silveira
Gonçalves, Nayara Magalhães
Oliveira, Jerusa Maria de
Henry, Marc
Neves, Mariana Machado
Abstract: Arsenic impairs male reproductive functions. However, it is not clear whether different arsenic compounds similarly affect fertility. In this study, we compared the impact of sodium arsenite and arsenate on sperm quality and fertility. After 56 d exposure, male Wistar rats were mated and pregnant females were evaluated by fertility indexes. Clearly, exposure to 10 mg/L arsenite reduced daily sperm production via H2O2 overproduction and germ cells loss. Animals from this group also showed a decrease in epididymal sperm counts and percentage of sperm with intact membranes. Moreover, they presented low fertility potential and high preimplantation loss. In contrast, 10 mg/L arsenate caused oxidative stress in testis, mineral imbalance in epididymis, and sperm membranes damage, with no effects on fertility. Both arsenic compounds at 0.01 mg/L altered reproductive parameters. We concluded that arsenite is more harmful than arsenate to sperm quality and male fertility, with negative influences in early pregnancy.
Palavras-chave: Arsenite
Arsenate
Reproductive toxicity
Sperm viability
Fertility potential
Trace elements imbalance
Editor: Reproductive Toxicology
Tipo de Acesso: Elsevier B. V.
URI: https://doi.org/10.1016/j.reprotox.2018.04.015
http://www.locus.ufv.br/handle/123456789/21960
Data do documento: 24-Abr-2018
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