Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/22064
Tipo: Artigo
Título: Multiscale models for the growth of avascular tumors
Autor(es): Martins, M. L.
Ferreira Jr., S. C.
Vilela, M. J.
Abstract: In the past 30 years we have witnessed an extraordinary progress on the research in the molecular biology of cancer, but its medical treatment, widely based on empirically established protocols, still has many limitations. One of the reasons for that is the limited quantitative understanding of the dynamics of tumor growth and drug response in the organism. In this review we shall discuss in general terms the use of mathematical modeling and computer simulations related to cancer growth and its applications to improve tumor therapy. Particular emphasis is devoted to multiscale models which permit integration of the rapidly expanding knowledge concerning the molecular basis of cancer and the complex, nonlinear interactions among tumor cells and their microenvironment that will determine the neoplastic growth at the tissue level.
Palavras-chave: Cancer growth
Spatio-temporal pattern formation
Multi-scale models
Editor: Physics of Life Reviews
Tipo de Acesso: Elsevier B.V.
URI: https://doi.org/10.1016/j.plrev.2007.04.002
http://www.locus.ufv.br/handle/123456789/22064
Data do documento: Jun-2007
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