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https://locus.ufv.br//handle/123456789/22761
Tipo: | Artigo |
Título: | Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice |
Autor(es): | Natali, Antonio J. Duarte, Hugo Leonardo L. Sales Jr, Policarpo A. Ropert, Catherine Gazzinelli, Ricardo T. Cruz, Jader S. Roman-Campos, Danilo |
Abstract: | Trypanosoma cruzi, an intracellular protozoan parasite infecting a wide variety of vertebrates, is the agent responsible for Chagas’ disease. This pathology often results in severe inflammatory heart condition and it is one of the major causes of dilated cardiomyopathy leading to heart failure in Latin America. Nevertheless, little is known about the changes in isolate cardiac myocytes contractility during the development of this pathology. Here we report a relationship between cytokines profile of mice infected with T. cruzi and the modifications in the cellular contractility pattern. We found that cellular contractility, measured as fractional shortening, showed a complex behavior. The changes were evaluated during the acute phase (15, 30 and 45 dpi) and chronic phase (>90 dpi). The time to half contraction and relaxation were lengthier despite the number of days after infection or the heart region evaluated. The maximal contraction and relaxation velocities were significantly slower. The observed changes in cellular contractility were correlated with the presence of circulating IFN-γ, TNF-α and MCP-1/CCL2 during the course of infection. Together, our data demonstrate that cellular contractility is altered in the three heart regions studied, and these alterations are observed at the very beginning of the parasitism and they remained until the chronic phase has been reached. Indeed, we propose a role for IFN-γ, TNF-α and MCP-1/CCL2 in the mechanical heart remodeling during experimental Chagas’ disease. |
Palavras-chave: | Trypanosoma cruzi Chagas’ disease Cellular contractility Cytokines Chemokines Cardiac chambers Heart failure |
Editor: | Basic Research in Cardiology |
Tipo de Acesso: | Steinkopff Verlag Darmstadt 2009 |
URI: | https://doi.org/10.1007/s00395-009-0776-x http://www.locus.ufv.br/handle/123456789/22761 |
Data do documento: | Mai-2009 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | Texto completo | 412,23 kB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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