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Accuracy of plasma interleukin-18 and adiponectin concentrations in predicting metabolic syndrome and cardiometabolic disease risk in middle-age Brazilian men

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dc.contributor.author Oliveira, Alessandro de
dc.contributor.author Hermsdorff, Helen Hermana
dc.contributor.author Cocate, Paula G.
dc.contributor.author Santos, Eliziaria C.
dc.contributor.author Bressan, Josefina
dc.contributor.author Natali, Antônio José
dc.date.accessioned 2019-02-26T14:38:57Z
dc.date.available 2019-02-26T14:38:57Z
dc.date.issued 2015
dc.identifier.issn 1715-5320
dc.identifier.uri https://doi.org/10.1139/apnm-2014-0487
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/23715
dc.description.abstract The aims of this cross-sectional study were to explore the ability of serum interleukin 18 (IL-18) and adiponectin to identify metabolic syndrome (MetS), and to verify their association with an index of central lipid overaccumulation (lipid accumulation product (LAP)) and cardiometabolic risk factors in a population of middle-aged Brazilian men. A group of 218 apparently healthy middle-aged Brazilian men (age, 50.3 ± 4.97 years) underwent anthropometric, clinical, sociodemographic, and standard serum biochemical assessments. LAP was calculated and the study participants were categorized into 3 groups according to serum IL-18 and adiponectin cut-points tertiles to verify the association of these biomarkers with cardiometabolic risk factors. The MetS group had more less active (p = 0.03) and obese (p < 0.01) individuals who exhibited higher IL-18 (p < 0.01) and lower adiponectin (p < 0.01) than did those in the group with no MetS. After adjustments (age, smoking, alcohol consumption, physical activity level, and total body fat), serum IL-18 ≥ 336.4 pg/mL was an independent factor for MetS occurrence and it was directly associated with LAP (≥51.28), central obesity, hypertriglyceridemia, and hypertension (p < 0.05), but not with high-density lipoprotein cholesterol (HDL-C). Serum adiponectin ≥ 7.02 μg/mL was negatively associated with MetS occurrence, LAP, hypertriglyceridemia, and low HDL-C (p < 0.05), but not with central obesity and hypertension. In conclusion, both IL-18 and adiponectin demonstrated the ability to identify MetS in this population, with IL-18 being more accurate. The association of these biomamarkers with LAP and cardiometabolic risk factors highlights its relevance as a diagnostic tool. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Applied Physiology, Nutrition, and Metabolism pt-BR
dc.relation.ispartofseries v. 40, n. 10, p. 1048-1055, 2015 pt-BR
dc.rights NRC Research Press pt-BR
dc.subject Cardiometabolic risk pt-BR
dc.subject Adipokines pt-BR
dc.subject Interleukins pt-BR
dc.subject Metabolic syndrome pt-BR
dc.title Accuracy of plasma interleukin-18 and adiponectin concentrations in predicting metabolic syndrome and cardiometabolic disease risk in middle-age Brazilian men en
dc.type Artigo pt-BR


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  • Artigos [398]
    Artigos Técnico-científicos nas áreas de Nutrição e Saúde

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