Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial

Show simple item record Lopes, Rita de Cássia Stampini Oliveira Theodoro, Jaqueline Maciel Vieira Silva, Bárbara Pereira da Queiroz, Valéria Aparecida Vieira Moreira, Maria Eliza de Castro Mantovani, Hilário Cuquetto Hermsdorff, Helen Hermana Martino, Hércia Stampini Duarte 2019-03-13T12:05:26Z 2019-03-13T12:05:26Z 2019-02
dc.identifier.issn 0963-9969
dc.description.abstract Generation of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the effect of synbiotic meal on uremic toxins in HD individuals. We conducted randomized singleblind and placebo-controlled intervention study with 58 HD subjects (20F/38M, 63.1 ± 10.9-old) who were randomly allocated in synbiotic group (SG, 40 g of extruded sorghum plus 100 mL of unfermented probiotic milk) or control group (CG, 40 g of extruded corn plus 100 mL of pasteurized milk), during 7-wk Metabolic markers and uremic toxins, fecal concentration of short chain fatty acid and pH value was determined. The SG group had decreased serum p-CS and IS, as well as decreased urea concentration (p < .05) compared to CG. SG showed higher fecal butyric acid and lower pH compared to baseline and SC (p < .05). In addition, serum p-CS and fecal pH were positively correlated to urea concentration in SG participants at the endpoint. The consumption of the synbiotic meal during 7-wk reduced colonic pH, and reduced serum uremic (p-CS and IS) toxins and urea in HD subjects. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Food Research International pt-BR
dc.relation.ispartofseries Volume 116, Pages 241-248, February 2019 pt-BR
dc.rights Elsevier B. V. pt-BR
dc.subject Bifidobacterium longum pt-BR
dc.subject Chronic kidney disease pt-BR
dc.subject Indoxyl sulfate pt-BR
dc.subject p-Cresylsulfate pt-BR
dc.subject Sorghum bicolor L. pt-BR
dc.subject Urea pt-BR
dc.title Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial en
dc.type Artigo pt-BR

Files in this item

This item appears in the following Collection(s)

  • Artigos [398]
    Artigos Técnico-científicos nas áreas de Nutrição e Saúde

Show simple item record

Search DSpace


My Account