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Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial

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dc.contributor.author Lopes, Rita de Cássia Stampini Oliveira
dc.contributor.author Theodoro, Jaqueline Maciel Vieira
dc.contributor.author Silva, Bárbara Pereira da
dc.contributor.author Queiroz, Valéria Aparecida Vieira
dc.contributor.author Moreira, Maria Eliza de Castro
dc.contributor.author Mantovani, Hilário Cuquetto
dc.contributor.author Hermsdorff, Helen Hermana
dc.contributor.author Martino, Hércia Stampini Duarte
dc.date.accessioned 2019-03-13T12:05:26Z
dc.date.available 2019-03-13T12:05:26Z
dc.date.issued 2019-02
dc.identifier.issn 0963-9969
dc.identifier.uri https://doi.org/10.1016/j.foodres.2018.08.024
dc.identifier.uri http://www.locus.ufv.br/handle/123456789/23905
dc.description.abstract Generation of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the effect of synbiotic meal on uremic toxins in HD individuals. We conducted randomized singleblind and placebo-controlled intervention study with 58 HD subjects (20F/38M, 63.1 ± 10.9-old) who were randomly allocated in synbiotic group (SG, 40 g of extruded sorghum plus 100 mL of unfermented probiotic milk) or control group (CG, 40 g of extruded corn plus 100 mL of pasteurized milk), during 7-wk Metabolic markers and uremic toxins, fecal concentration of short chain fatty acid and pH value was determined. The SG group had decreased serum p-CS and IS, as well as decreased urea concentration (p < .05) compared to CG. SG showed higher fecal butyric acid and lower pH compared to baseline and SC (p < .05). In addition, serum p-CS and fecal pH were positively correlated to urea concentration in SG participants at the endpoint. The consumption of the synbiotic meal during 7-wk reduced colonic pH, and reduced serum uremic (p-CS and IS) toxins and urea in HD subjects. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Food Research International pt-BR
dc.relation.ispartofseries Volume 116, Pages 241-248, February 2019 pt-BR
dc.rights Elsevier B. V. pt-BR
dc.subject Bifidobacterium longum pt-BR
dc.subject Chronic kidney disease pt-BR
dc.subject Indoxyl sulfate pt-BR
dc.subject p-Cresylsulfate pt-BR
dc.subject Sorghum bicolor L. pt-BR
dc.subject Urea pt-BR
dc.title Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial en
dc.type Artigo pt-BR


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  • Artigos [398]
    Artigos Técnico-científicos nas áreas de Nutrição e Saúde

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