Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity

Show simple item record Fernandes, Kenner Morais Tomé, Hudson Vaner Ventura Miranda, Franciane Rosa Gonçalves, Wagner Gonzaga Pascini, Tales Vicari Serrão, José Eduardo Martins, Gustavo Ferreirapt-BR 2019-03-13T18:20:52Z 2019-03-13T18:20:52Z 2019-04
dc.identifier.issn 0045-6535
dc.description.abstract The mosquito Aedes aegypti is the main vector of Dengue, Chikungunya, Zika, and yellow fever viruses, which are responsible for high human morbidity and mortality. The fight against these pathogens is mainly based on the control of the insect vector with the use of insecticides. Among insecticides, spinosad bioinsecticide is efficient against A. aegypti larvae and may be an alternative for vector control. Here, we investigate the sublethal effects of spinosad during midgut metamorphosis of A. aegypti females and its cumulative effects on blood acquisition capacity and fecundity in adults. We studied the midgut because it is an important model organ directly related to blood acquisition and digestion. Treatment of larvae with spinosad induced oxidative stress, apoptosis, and damage to the midgut cells at all stages of development and in adults. There was a reduction in the number of proliferating cells and the number of enteroendocrine cells in treated individuals. In addition, damage caused by spinosad led to a reduction in oviposition and egg viability of A. aegypti females. Finally, the exposure of mosquito larvae to sublethal concentrations of spinosad interfered with the development of the midgut, arresting the blood digestion and reproduction of adult females with blood digestion and reproduction difficulties. en
dc.format pdf pt-BR
dc.language.iso eng pt-BR
dc.publisher Chemosphere pt-BR
dc.relation.ispartofseries Volume 221, Pages 464-470, April 2019 pt-BR
dc.rights Elsevier B. V. pt-BR
dc.subject Apoptosis pt-BR
dc.subject Bioinsecticide pt-BR
dc.subject Metamorphosis pt-BR
dc.subject Mosquitoes pt-BR
dc.subject Insecticide toxicity pt-BR
dc.title Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity en
dc.type Artigo pt-BR

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    Artigos Técnico-científicos na área de Biologia Geral

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