Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/24004
Tipo: Artigo
Título: Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue
Autor(es): Rodrigues, Aurora Corrêa
Leal, Tiago Ferreira
Costa, Alexandre Jayme Lopes Dantas
Silva, Franciany de Jesus
Soares, Leôncio Lopes
Brum, Patrícia Chakur
Hermsdorff, Helen Hermana Miranda
Peluzio, Maria do Carmo Gouveia
Prímola-Gomes, Thales Nicolau
Natali, Antônio José
Abstract: Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue. Four- to five-month-old male wild type (WT) and β1-AR−/− mice were divided into groups: WT control (WTc) and trained (WTt); and β1-AR−/− control (β1-AR−/−c) and trained (β1-AR−/−t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. After euthanasia, white epididymal (eWAT) and inguinal (iWAT) and brown (BAT) adipose tissues were dissected and used to determine: adiposity index; adipocyte histomorphometry; cytokine concentration; and gene expression. The content of fat, protein and water of the empty carcass was determined. MCAE reduced body weight, fat mass as well as iWAT and BAT adipocyte area in β1-AR−/− animals. Aerobic exercise also diminished the concentrations of pro-inflammatory (IL-12p70, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in adipose tissue (iWAT, eWAT or BAT) of β1-AR−/− mice. However, MCAE had no effect on the expression lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue. Alongside reductions in body weight, fat mass and adipocyte area eight weeks of MCAE improves the profile of inflammatory cytokines in β1-AR−/− mice adipose tissue, despite no change in Lipolytic and thermogenic gene expression.
Palavras-chave: Moderate exercise
Adipocyte
Lipolytic genes
Inflammatory cytokines
Editor: Life Sciences
Tipo de Acesso: Elsevier B. V.
URI: https://doi.org/10.1016/j.lfs.2019.02.031
http://www.locus.ufv.br/handle/123456789/24004
Data do documento: 15-Mar-2019
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