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https://locus.ufv.br//handle/123456789/30956
Tipo: | Artigo |
Título: | Serum concentration of acute phase proteins and cytokines in vaccinated pigs challenged with foot-and-mouth disease virus serotype O |
Autor(es): | Lee, Kyung-Woo Lee, Kwang-Nyeong Lillehoj, Hyun S. Park, Jong-Hyeon |
Abstract: | The present study aimed to investigate the kinetics of acute phase proteins and cytokines in the serum of immunized or naive pigs following infection with a field isolate of foot-and-mouth disease (FMD) virus. Five-month-old SPF pigs were intramuscularly immunized with or without the 146S antigen (7.5 μg per head) purified from FMD virus (O/Andong/SKR/2010) and were subsequently challenged 30 days post-vaccination (dpv) with FMD virus on each footpad. Serum samples were obtained at 28 dpv and on days 1, 3, and 5 post-infection (dpi). At 28 dpv, the serum concentrations of C-reactive protein and tumor necrosis factor alpha (TNF-α) were higher in the immunized pigs compared with the non-immunized control pigs. Upon challenge, the levels of all measured acute phase proteins (i.e., C-reactive protein, major acute phase protein, S-amyloid A, and haptoglobin) plateaued at 1 dpi in the immunized pigs whereas they gradually increased up to 5 dpi in the non-immunized control pigs. Levels of serum TNF-α remained higher in the immunized challenged pigs compared with the non-immunized challenged pigs. The serum concentration of interleukin (IL)-6 in the immunized challenged pigs was undetectable at all time points, but moderately increased upon challenge in the non-immunized challenged pigs. IL-1β was not detected in any of the pigs at any of the observed time points. Collectively, these findings show that the immunized pigs exhibit a rapid serum acute phase protein response following subsequent challenge with the field FMD virus compared with the non-immunized pigs |
Palavras-chave: | C-reactive protein immune response major acute phase protein tumor necrosis factor alpha |
Editor: | Brazilian Journal of Animal Science |
Citação: | Lee, K.-W.; Lee, K.-N.; Lillehoj, H. S. and Park, J.-H. 2019. Serum concentration of acute phase proteins and cytokines in vaccinated pigs challenged with foot-and-mouth disease virus serotype O. Revista Brasileira de Zootecnia 48:e20180190 |
Tipo de Acesso: | Creative Commons Attribution License |
Identificador DOI: | https://doi.org/10.1590/rbz4820180190 |
URI: | https://locus.ufv.br//handle/123456789/30956 |
Data do documento: | 29-Mar-2019 |
Aparece nas coleções: | Artigos |
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1806-9290-rbz-48-e20180190.pdf | artigo | 349,59 kB | Adobe PDF | Visualizar/Abrir |
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