Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/12844
Tipo: Artigo
Título: Swimming training attenuates contractile dysfunction in diabetic rat cardiomyocytes
Autor(es): Silva, Márcia Ferreira da
Pelúzio, Maria do Carmo Gouveia
Amorim, Paulo Roberto dos Santos
Lavorato, Vitor Neiva
Santos, Natália Pereira do
Bozi, Luiz Henrique Marchesi
Penitente, Arlete Rita
Falkoski, Daniel Luciano
Berfort, Felipe Gomes
Natali, Antonio Jose
Abstract: Experimental diabetes promotes contractile dysfunction in cardiomyocytes, but the effects of swimming in this disorder are not known. To test the effects of a swimming training program (STP) on cardiomyocyte contractile dysfunction in rats with experimental diabetes. Wistar rats (age: 30 days; mean body weight: 84.19 g) with diabetes induced by streptozotocin (60 mg/kg body weight; glucose > 300 mg/dl) were divided into sedentary diabetic rats (SD, n = 10) and exercised diabetic rats (ED, n = 13). Animals of same age and weight served as sedentary controls (SC, n = 10) and exercised controls (EC, n = 06). Animals and ED and EC underwent a STP (05 days/week, 90 min/day) for 08 weeks. Left ventricular (LV) myocytes were isolated and electrically stimulated at 3.0 Hz at room temperature (∼ 25º C). Diabetes reduced contractile function in cardiomyocytes of animals compared to controls (i.e., lower amplitude of contraction, longer duration of contraction and relaxation). The STP attenuated the reduced amplitude of contraction (SC, 11 ± 0.2% vs ED, 11.6 ± 0.2%), time to peak contraction (SC, 319 ± 5.8 ms vs ED, 333 ± 4.8 ms) and time to 50.0% of relaxation (SC, 619 ± 22.2 ms vs ED 698 ± 18.6 ms) of cardiomyocytes of diabetic rats. Diabetes reduced the size of cardiomyocytes, however, the STP minimized the reduction of cell volume and width, without changing length. The swimming training program attenuated the contractile dysfunction of the LV myocytes of rats with experimental diabetes.
Palavras-chave: Swimming
Physical exertion
Myocytes
Cardiac
Rats
Diabetes mellitus
Editor: Arquivos Brasileiros de Cardiologia
Tipo de Acesso: Open Access
URI: http://dx.doi.org/10.1590/S0066-782X2011005000055
http://www.locus.ufv.br/handle/123456789/12844
Data do documento: 21-Dez-2010
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