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https://locus.ufv.br//handle/123456789/12844
Tipo: | Artigo |
Título: | Swimming training attenuates contractile dysfunction in diabetic rat cardiomyocytes |
Autor(es): | Silva, Márcia Ferreira da Pelúzio, Maria do Carmo Gouveia Amorim, Paulo Roberto dos Santos Lavorato, Vitor Neiva Santos, Natália Pereira do Bozi, Luiz Henrique Marchesi Penitente, Arlete Rita Falkoski, Daniel Luciano Berfort, Felipe Gomes Natali, Antonio Jose |
Abstract: | Experimental diabetes promotes contractile dysfunction in cardiomyocytes, but the effects of swimming in this disorder are not known. To test the effects of a swimming training program (STP) on cardiomyocyte contractile dysfunction in rats with experimental diabetes. Wistar rats (age: 30 days; mean body weight: 84.19 g) with diabetes induced by streptozotocin (60 mg/kg body weight; glucose > 300 mg/dl) were divided into sedentary diabetic rats (SD, n = 10) and exercised diabetic rats (ED, n = 13). Animals of same age and weight served as sedentary controls (SC, n = 10) and exercised controls (EC, n = 06). Animals and ED and EC underwent a STP (05 days/week, 90 min/day) for 08 weeks. Left ventricular (LV) myocytes were isolated and electrically stimulated at 3.0 Hz at room temperature (∼ 25º C). Diabetes reduced contractile function in cardiomyocytes of animals compared to controls (i.e., lower amplitude of contraction, longer duration of contraction and relaxation). The STP attenuated the reduced amplitude of contraction (SC, 11 ± 0.2% vs ED, 11.6 ± 0.2%), time to peak contraction (SC, 319 ± 5.8 ms vs ED, 333 ± 4.8 ms) and time to 50.0% of relaxation (SC, 619 ± 22.2 ms vs ED 698 ± 18.6 ms) of cardiomyocytes of diabetic rats. Diabetes reduced the size of cardiomyocytes, however, the STP minimized the reduction of cell volume and width, without changing length. The swimming training program attenuated the contractile dysfunction of the LV myocytes of rats with experimental diabetes. |
Palavras-chave: | Swimming Physical exertion Myocytes Cardiac Rats Diabetes mellitus |
Editor: | Arquivos Brasileiros de Cardiologia |
Tipo de Acesso: | Open Access |
URI: | http://dx.doi.org/10.1590/S0066-782X2011005000055 http://www.locus.ufv.br/handle/123456789/12844 |
Data do documento: | 21-Dez-2010 |
Aparece nas coleções: | Artigos |
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