Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/18731
Tipo: Artigo
Título: Low doses of simvastatin potentiate the effect of sodium alendronate in inhibiting bone resorption and rtestore microstructural and mechanical bone properties in Glucocorticoid-Induced Osteoporosis
Autor(es): Sequetto, Priscila L.
Gonçalves, Reggiani V.
Pinto, Aloísio S.
Oliveira, Maria G. A.
Maldonado, Izabel R. S. C.
Oliveira, Tânia T.
Novaes, Rômulo D.
Abstract: By using an experimental model of dexamethasone-induced osteoporosis we investigated the effects of different therapeutic schemes combining sodium alendronate (SA) and simvastatin on bone mineral and protein composition, microstructural and mechanical remodeling. Wistar rats were randomized into eight groups: G1: non-osteoporotic; G2: osteoporotic; G3, G4, and G5: osteoporotic + SA (0.2, 0.4, and 0.8 mg/kg, respectively); G6, G7, and G8: osteoporotic + SA (0.2, 0.4, and 0.8 mg/kg, respectively) + simvastatin (0.4, 0.6, and 1 mg/kg, respectively). Osteoporosis was induced by dexamethasone (7 mg/kg, i.m.) once a week for 5 weeks. All treatments were administered for 8 weeks. Dexamethasone increased serum levels of alkaline phosphatase, calcium, phosphorus, and urea, especially in non-treated animals, which showed severe osteoporosis. Dexamethasone also induced bone microstructural fragility and reduced mechanical resistance, which were associated with a marked depletion in mineral mass, collagenous and non-collagenous protein levels in cortical and cancellous bone. Although SA has attenuated osteoporosis severity, the effectiveness of drug therapy was enhanced combining alendronate and simvastatin. The restoration in serum parameters, organic and inorganic bone mass, and mechanical behavior showed a dose-dependent effect that was potentially related to the complementary mechanisms by which each drug acts to induce bone anabolism, accelerating tissue repair.
Palavras-chave: Bone
Glucocorticoid
Microanalysis
Pathology
Scanning electron microscopy
Editor: Microscopy and Microanalysis
Tipo de Acesso: Microscopy Society of America
URI: https://doi.org/10.1017/S1431927617012363
http://www.locus.ufv.br/handle/123456789/18731
Data do documento: 19-Jun-2017
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