Use este identificador para citar ou linkar para este item: https://locus.ufv.br//handle/123456789/19224
Tipo: Artigo
Título: Changes in the Salmonella enterica Enteritidis phenotypes in presence of acyl homoserine lactone quorum sensing signals
Autor(es): Campos‐Galvão, Maria Emilene Martino
Ribon, Andrea Oliveira Barros
Araújo, Elza Fernandes
Vanetti, Maria Cristina Dantas
Abstract: Quorum sensing is used by bacteria to coordinate gene expression in response to population density and involves the production, detection and response to extracellular signaling molecules known as autoinducers (AIs). Salmonella does not synthesize the AI-1, acyl homoserine lactone (AHL) common to gram-negative bacteria; however, it has a receptor for AI-1, the SdiA protein. The effect of SdiA in modulating phenotypes of Salmonella has not been elucidated. In this report, we provide evidence that the AIs-1 affect Salmonella enterica serovar Enteritidis behavior by enhancing the biofilm formation and expression of virulence genes under anaerobic conditions. Biofilm formation by Salmonella was detected by the crystal violet method and by scanning electron microscopy. The presence of AHLs, particularly C12-HSL, increased biofilm formation and promoted expression of biofilm formation genes (lpfA, fimF, fliF, glgC) and virulence genes (hilA, invA, invF). Our results demonstrated that AHLs produced by other organisms played an important role in virulence phenotypes of Salmonella Enteritidis.
Palavras-chave: Salmonella Enteritidis
Quorum sensing
Virulence
Biofilm
AHL
Editor: Journal of Basic Microbiology
Tipo de Acesso: Open Access
URI: https://doi.org/10.1002/jobm.201500471
http://www.locus.ufv.br/handle/123456789/19224
Data do documento: 11-Nov-2015
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