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https://locus.ufv.br//handle/123456789/23631
Tipo: | Artigo |
Título: | Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats |
Autor(es): | Moreira, Maria Eliza de Castro Araújo, Fernanda de Oliveira Sousa, Andressa Rodrigues de Toledo, Renata Celi Lopes Benjamin, Laércio dos Anjos Santos, Marcelo Henrique dos Martino, Hercia Stampini Duarte Veloso, Marcia Paranho Reis, Kassius de Souza |
Abstract: | The aim was to evaluate the effect of the ethanol extract of bacupari peel (EEB) on biometric measurements, hepatic lipogenesis and progression of non-alcoholic fatty liver disease (NAFLD) in obese Wistar rats. Chemical analysis of the bacupari peel extract identified 7-epiclusianone as the major constituent (140.02 mg/g) followed by morelloflavone (35.86 mg/g). Animals treated with high fat diet plus EEB (BHFD) reduced body mass index (BMI), liver weight and hepatosomatic index in relation to the obese control. The food intake was similar between hyperlipid group (HFD) groups with or without EEB. However, the normal control group (AIN-93 M) presented higher food intake and lower final weight compared to the obese control (HFD). The PPAR-α, CPT-1a and the ADIPOR2 genes expressions, and the concentration of the PPAR-α and the adiponectin protein level increased in the BHFD group in relation to the obese control. The EEB promoted reduction of the SREBP-1c gene expression and the percentage of hepatic fat and the degree of steatosis in relation to HFD. It was concluded that EEB showed a protective effect on NAFLD, as it promoted a reduction in BMI, induced lipid oxidation, reduced lipogenesis and hepatic steatosis. Moreover, our results suggest an interaction that can lead to an agonist activity of the EEB to the PPAR-α receptor. |
Palavras-chave: | Adiponectin ADIPOR2 Nonalcoholic fatty liver disease PPAR-ɑ Rheedia brasiliensis |
Editor: | Food Research International |
Tipo de Acesso: | 2018 Elsevier Ltd. All rights reserved. |
URI: | https://doi.org/10.1016/j.foodres.2018.08.004 http://www.locus.ufv.br/handle/123456789/23631 |
Data do documento: | Dez-2018 |
Aparece nas coleções: | Artigos |
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Arquivo | Descrição | Tamanho | Formato | |
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artigo.pdf Until 2100-12-31 | Texto completo | 2,15 MB | Adobe PDF | Visualizar/Abrir ACESSO RESTRITO |
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